| 名稱 | AI-Edigene® FGFR3 p.S249C Reference Standard |
| 型號 | CBP10553 |
| 報價 |  |
| 特點 | AI-Edigene® FGFR3 p.S249C Reference Standard Plus |
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基因檢測標(biāo)準(zhǔn)品 > Mutation > CBP10553AI-Edigene® FGFR3 p.S249C Reference Standard
- 詳細(xì)內(nèi)容
CBP10553 | |
| Format | Genomic DNA |
| Description | FGFR3, fibroblast growth factor receptor 3, is a receptor tyrosine kinase activated upon binding of the FGF ligand, which activates RAS-MAPK and PI3K-AKT pathways (PMID: 22508544). Altered function of FGFR3 in cancer may lead to increased cell proliferation and decreased apoptosis (PMID: 22508544) and mutations and fusions are commonly observed in bladder cancer (PMID: 30975452, PMID: 23175443). |
| Technical Data | |
| DNA Change: | c.746C>G |
| AA Change | p.S249C |
| Mutation type | Substitution - Missense |
| Zygosity | Heterozygous |
| Allelic Frequency | 50.00% |
| Transcript | NM_000142.5 |
| Cosmic ID | COSM715 |
| Chr position(GRCh37) | chr4:1803568 |
| Buffer: | Tris-EDTA |
| Product Information | |
| Intended Use | Research Use Only |
| Unit Size | 1ug |
| Concentration | Download for COA |
| Purity | Download for COA |
| DNA electrophoresis | Download for COA |
| Sanger sequencing |
|
| Storage | 4℃ |
| Expiry | 36 months from the date of manufacture |
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