| 名稱(chēng) | AI-Edigene® NRAS p.G12V Reference Standard Pl |
| 型號(hào) | CBP10523 |
| 報(bào)價(jià) |  |
| 特點(diǎn) | AI-Edigene® NRAS p.G12V Reference Standard Plus |
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基因檢測(cè)標(biāo)準(zhǔn)品 > Mutation > CBP10523AI-Edigene® NRAS p.G12V Reference Standard Pl
- 詳細(xì)內(nèi)容
CBP10523 | |
| Format | Genomic DNA |
| Description | NRAS G12V is a hotspot mutation that lies within a GTP-binding region of the Nras protein (UniProt.org). G12V confers a loss of function on Nras protein as indicated by accumulation of GTP-bound Nras, loss of GTPase-activating protein sensitivity, leading to increased downstream pathway activation in cell culture (PMID: 19966803). |
| Technical Data | |
| DNA Change: | c.35G>T |
| AA Change | p.G12V |
| Mutation type | Substitution - Missense |
| Zygosity | Homozygous |
| Allelic Frequency | 100% |
| Transcript | NM_002524.5 |
| Cosmic ID | COSM566 |
| Chr position(GRCh37) | chr1:115258747 |
| Buffer: | Tris-EDTA |
| Product Information | |
| Intended Use | Research Use Only |
| Unit Size | 1ug |
| Concentration | Download for COA |
| Purity | Download for COA |
| DNA electrophoresis | Download for COA |
| Sanger sequencing |
|
| Storage | 4℃ |
| Expiry | 36 months from the date of manufacture |
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